Senior Research Associate 1, DMPK

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Job description

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon's discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.

Position

We are seeking a highly experienced and motivated Senior Research Associate 1 with a focus on Drug Metabolism and Pharmacokinetics (DMPK) to join our team. The successful candidate will contribute to the laboratory efforts to support Eikon drug discovery programs. As a Senior Research Associate 1, you will leverage your expertise to design and execute complex experiments, collaborate with interdisciplinary teams, and drive the development of innovative solutions.

About You

The ideal candidate for this role will have demonstrated proficiency in a wide range of in vitro ADME studies, including liver microsome stability, hepatocytes stability, and plasma protein binding highlighting their expertise in ADME. Proficiency in mass spectrometry operation, maintenance and troubleshooting. Your strong organizational skills and attention to detail ensure precision, accuracy, and reliability in experimental outcomes. You are known for your proven ability to work independently and drive research projects to successful completion, while also being adaptable and responsive to evolving research priorities and challenges in a fast-paced environment.

What You'll Do

• Design and execute in vitro ADME studies to understand the properties of novel chemicals, including liver microsome stability, hepatocytes stability and plasma protein binding, etc.
• Perform bioanalytical method development and analysis of small molecules using the LC/MS-MS. Experience with Analyst and DiscoveryQuant is a plus.
• Analyze experimental data using appropriate software and statistical methods and provide clear and concise summaries of findings to support decision making.
• Maintain detailed records of experimental procedures, results, and observations in laboratory notebooks and databases.
• Ensure proper maintenance and organization of laboratory equipment, reagents, and supplies. Adhere to safety protocols and maintain a clean and safe working environment. Experience with programing liquid handling automation would be a plus.
• Interact with external CROs to perform required ADME/PK studies (pre-clinical and IND enabling) including protocol development, timelines, data analysis/interpretation and report writing.
• Prepare technical reports and presentations for internal meetings and regulatory submissions.
• Collaborate effectively with cross-functional teams, including medicinal chemistry, pharmacology, and toxicology, to support drug discovery and development projects.

Qualifications

• Master's degree with 2 years of experience or Bachelor's with 4 years of related experience in Biology, Bioengineering, Biotechnology, or a related field.
• Extensive hands-on experience with a variety of in vitro ADME assays, including metabolic stability, plasma protein binding, CYP inhibition, and cell permeability.
• Proficiency in data analysis software and tools commonly used in DMPK research.
• Proven ability to lead and manage complex experiments independently, demonstrating attention to detail.
• Excellent communication skills, enabling effective interaction with team members and contributing to a collaborative scientific environment.
• Fundamental understanding of in vitro ADME properties such as permeability and transporters, well-stirred model, and DDI.
• Adaptable and responsive to evolving research priorities and challenges in a fast-paced environment.

At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:

• 401k plan with company matching
• Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
• Mental health and wellness benefits
• Weeklong summer and winter holiday shutdowns
• Generous paid time off and holiday policies
• Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
• Enhanced parental leave benefit
• Daily subsidized lunch program when on-site

The expected salary range for this role is $97,000 to $106,400 depending on skills, competency, and the market demand for your expertise.

Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

In accordance with the Company's duty to provide and maintain a safe workplace, the Company requires all employees to be Fully Vaccinated with one of the FDA approved COVID-19 vaccines, which includes those vaccines that have received the FDA's emergency use authorization. You will be expected to be Fully Vaccinated as of your Start Date. If you believe that you are exempt from this requirement under an applicable law or regulations, including Americans with Disabilities Act and California's Fair Employment and Housing Act, you will need to contact the Company's Human Resources group. For purposes of this section, Fully Vaccinated means (i) the completion of the vaccination regimen as approved by the FDA (by way of example, 2 doses of the Pfizer or Moderna vaccine and 1 dose of the Johnson and Johnson vaccine), and (ii) timely receiving booster vaccination, as recommended by the Centers for Disease Control and Prevention.

We are currently not accepting any new third-party agencies or firms at this time. Please do not forward unsolicited agency resumes to our website, employees or Human Resources. Eikon Therapeutics will not pay fees to any third-party agency or firm associated with unsolicited resumes.

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