Physician Scientist (Translational Genetic Diseases)

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Job description

We are looking for a dedicated physician-scientist with a strong background in human genetics to join our multi-disciplinary Cardiovascular, Metabolic and Skeletal disease Therapeutic Area Genetics (TAG) team at the Regeneron Genetics Center (RGC).

As a physician-scientist, you will take a leading role in the RGCs translational genetics program. This will include multimodal phenotyping in the RGCs vast collection of cohorts; designing and implementing large-scale genetic and epidemiologic investigations; mining data to identify potential targets for treatment and prevention of a wide array of human diseases; and driving translation of genetic insights. You will work in close collaboration with various colleagues at the RGC and Regeneron more broadly, including scientists and clinicians in our pre-clinical biology and clinical development teams. This position will grant you the opportunity to develop deep expertise in the applications of human genetics to all stages of drug discovery and development, and to play a leading role in the discovery and translation of tomorrows transformative therapies.

As a Physician Scientist, a typical day might include the following:

• Working with a multidisciplinary team of scientists, bioinformaticians, statistical geneticists, physician-scientists, and other members to design, implement and interpret large-scale human genetics studies.

• Mining and interpreting genetic association results to identify causal genes and variants, and to prioritize candidate drug targets, in collaboration with RGC and broader Regeneron colleagues.

• Generating, summarizing, and communicating results in meetings to various audiences; leading or contributing to the writing of scientific reports and publications.

• Working with colleagues in clinical development to apply genetic data and insights to the design, conduct or interpretation of clinical research activities.

• Using your clinical experience and medical knowledge to define high-quality and refined phenotypes for genetic discovery and target validation.

• Representing the TAG team in cross-functional initiatives within RGC and Regeneron.

• Collaborating with industry and academic partners in collaborations of strategic interest to the RGC.

• Preparing tables, figures, written reports, and results summaries; Drafting portions of scientific manuscripts, internal reports, and patent applications.

This job might be for you if you have:

• A passion for using your medical and scientific expertise to understanding the genetic basis and causes of cardiometabolic diseases, and translating this knowledge into therapeutic insights. An outstanding candidate will have previous experience with phenotypes related to these diseases.

• A demonstrated ability to design and lead human genetics studies delivering medically relevant findings in a team-based environment.

• Experience leading complex human genetics research endeavors, have knowledge of study designs and analyses, including GWAS, exome, or genome sequencing in a cohort, case-control, or family-based studies, and can integrate data resources to translate initial findings.

• Outstanding communication skills and an ability to summarize and present the results of human genetic studies to a variety of audiences.

• You thrive in a highly interactive environment with a diverse team of colleagues and a commitment to promoting a collegial and highly inclusive working culture.

• You are committed to high-quality science, the highest research standards, work ethics, and integrity.

To be considered for this role, you must have an MD or MD/Ph.D. with a strong background in and knowledge of human genetics or genetic epidemiology, training and experience in translational human genetics, genetic epidemiology (or related fields), and strong quantitative skills. Familiarity with the applications of statistical genetics to gain medical insights including polygenic scores, quantitative traits analyses, rare variant analyses (e.g. burden tests), GWAS and Mendelian randomization, and familiarity with command-line interface, programming languages, and statistical software (eg. R, Python). Experience with the use of genetics in combination with other omics technologies (eg. metabolomics, proteomics, transcriptomics) is preferred. Must be onsite at least 3 days a week.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$170,100.00 - $277,500.00

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