Scientist- Bioassay Development and Safety Sciences (Cambridge, MA)

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Job description

We are seeking a highly motivated and enthusiastic Scientist to join our Bioassay Development and Safety Sciences team at Regeneron Cell Medicines (RCM). You will be involved in performing molecular and cellular assays for analysis of biological samples from both preclinical discovery research experiments and nonclinical studies (both pharmacology and safety) that support regulatory submissions.

The Bioassay Development and Safety Sciences team works with Regeneron Cell Medicines discovery platforms and translational research teams to generate the hypotheses, mechanism-of-action, and efficacy data that fuel the research pipeline. We also work with our non-clinical and regulatory teams to generate the pharmacology, PK/PD, safety, and biomarker data that is critical to translating each of Regeneron Cell Medicines innovative therapies safely from research into patients and to the market.

As a Scientist, a typical day might include:

• Contributing to experimental design, development, qualification/validation, execution and analysis of assays to support preclinical assay development across RCMs pipeline of T cell therapies

• Conducting DNA and RNA extraction, qPCR and ddPCR, and data analysis.

• Performing cell-based assays using aseptic technique, such as: flow cytometry and immunophenotyping; culture of tumor cell lines, human T cells, normal primary cells, as well as cocultures of cells.

• Performing ligand binding assays such as MSD and ELISA on serum samples derived from in vivo studies or supernatant from coculture experiments.

• Optimizing current assay offerings to increase assay robustness or sensitivity.

• Reviewing, organizing, and presenting research data to functional team.

• Providing critical lab support while working in a collaborative team environment

• Writing, reviewing, and approving technical documentation including development protocols, reports, batch records, and SOPs

This role might be for you if you:

• Demonstrate the ability to creatively resolve project hurdles by applying technical expertise in molecular and cellular biology

• Are scientifically rigorous, highly organized, and have excellent attention to detail

• Have the ability to quickly adapt to new research areas and implement new techniques independently

• Are able to work in a team environment, meet deadlines, and prioritize and balance work from multiple sources

• Are self-motivated, detail oriented, flexible, and have excellent organizational & communication skills

In order to be considered for this role, you must have at least a Bachelors/Masters degree in biology, cell biology, microbiology, biochemistry, bioengineering, biophysics, or related field and 6+ years of relevant experience. Must have experience with standard molecular and cellular biology techniques, including but not limited to, cell culture, PCR, RT-PCR, qPCR, ddPCR, and ligand binding assays. Experience culturing T-cells and tumor cells is preferred. Experience running flow cytometry is required. Familiarity/experience with MaxQuant is preferred. Experience with experimental design and maintaining a detailed electronic laboratory notebook is needed.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$90,700.00 - $148,100.00

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