Scientist I- RAS Mass Spectrometry

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Job description

Scientist I- RAS Mass Spectrometry

Job ID: req4065
Employee Type: exempt full-time
Division: Cancer Research Technology Program
Facility: Frederick: ATRF
Location: 8560 Progress Dr, Frederick, MD 21701 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

PROGRAM DESCRIPTION

The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.

KEY ROLES/RESPONSIBILITIES

• Conduct a range of independent and collaborative NCI RAS Initiative projects encompassing bottom-up, top-down, native, and quantitative proteomic applications
• Perform novel proteomic method development for the analysis of unique and challenging targets
• Support assay development for protein and PTM quantitation by peptide or proteoform reaction monitoring (PRM, PfRM)
• Assist with the daily operation and routine maintenance of three Orbitrap-based LC-MS platforms (currently an Exactive Plus EMR, an Orbitrap Fusion Lumos, and an Orbitrap Exploris 480)
• Attend project meetings, provide updates to collaborators, contribute substantially to publications, and present research findings at conferences or symposia

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

• Possession of a PhD degree in Chemistry, Biochemistry, Molecular Biology, or a related field from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Foreign degrees must be evaluated for U.S. equivalency
• Knowledge or experience in sample preparation, data acquisition, and data analysis for quantitative proteomics and/or top-down proteomics (with accompanying publication record)
• Demonstrated experience in operating and maintaining Orbitrap-based instruments and or experience in FTMS or FT-ICR-MS on Thermo or Bruker instruments
• Demonstrated ability to independently lead projects, balance changing priorities, collaborate with a team, and perform troubleshooting to ensure timely project completion
• Ability to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:

• Prior experience in top-down proteomic applications (global and targeted), crosslinking mass spectrometry for structural biology applications, or native mass spectrometry of membrane protein complexes
• Prior experience in protein purification, protein biochemistry, and standard molecular biology workflows

JOB HAZARDS

• This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations
• This position is subject to working with or have the potential for exposure to laser emissions, requiring medical clearance

Commitment to Diversity
All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.

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