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Senior Scientist II, AbbVie Biotherapeutics

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AbbVie

2024-10-04 00:45:27

Job location South San Francisco, California, United States

Job type: fulltime

Job industry: Science & Technology

Job description

Job Description

Key Responsibilities

Conceive & execute novel scientific research or development that achieves projects & area goals.

Generate new scientific proposals & lead those efforts.

Investigate, identify, develop, & optimize new methods & techniques.

Act as a lead in area of expertise & critically evaluate relevant scientific & regulatory advances & integrate this knowledge into research or development programs.

Conceive & implement novel experimental approaches to answer scientific questions & enable the development of antibody drug conjugates (ADCs) for the treatment of cancer.

Responsible for conceiving & performing studies, as well as analyzing & interpreting results & effectively communicate findings in a group setting.

Maintain solid understanding & hands-on-experience assessing key cancer cell signaling pathways such as investigating, identifying, developing, & optimizing new methods & techniques that inform on pathway/drug mechanisms of action such as flow cytometry, biochemical assays, reporter assays, or gene over-expression/knockdown.

Identify, develop, & optimize new methods & techniques that inform on ADC/payload mechanism of actions using flow cytometry, biochemical assays, reporter assays or gene overexpression/knockdown.

Perform flow cytometry studies to interrogate antibody binding to cells of interest and analysis using FlowJo.

Generate & analyze omic datasets such as scRNAseq, RNA-seq or phospho-proteomic datasets to identify pharmacodynamic (PD) or resistance biomarkers.

Responsible for validating PD & resistance biomarker utilizing immunoblot, qRT-PCR or flow cytometry.

Understand & adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug & radioactive compounds, GxP compliance, & animal care where applicable.

Responsible for leading presentations at International Scientific meetings.

Manage & oversee lower-level scientists within division.

Conduct medium- or high- throughput compound screening to identify combination partners that are clinically actionable & demonstrate the strength of their interaction utilizing synergy calculating software

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