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Bioconjugation Chemistry Scientist 1

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Talent Software Services, Inc.

2024-11-06 04:40:35

Job location San Rafael, California, United States

Job type: fulltime

Job industry: Science & Technology

Job description

Duties:

Synthesis, optimization, and high-quality delivery of various polymer, protein/peptide, and lipidated bioconjugates in support of discovery and development of Client therapeutics, with an emphasis on oligonucleotides

Development and implementation of new linker chemistries/spacers and bioconjugation methods for targeted drug delivery

Leveraging appropriate purification and analytical characterization approaches for QC and validation

Collaboration with internal and external partners for material transfer to support in vitro and in vivo POC experiments; assemble data packages and maintain quality control documentation through Benchling for final product delivery.

Effectively partner with cross-functional teams, sharing insights, troubleshooting issues, and driving science forward from the bench

Serve independently as bioconjugation technical lead and subject matter expert for internal and external project communications

Perform data analysis, interpret, and present results during internal and external meetings; attend and participate in scientific proceedings.

Prepare and optimize chemistry SOPs

Participate and present data and share responsibility for project milestones

Skills:

Extensive experience with different bioconjugation strategies and optimizations thereof for polymers, proteins/peptides, lipids, oligonucleotides and other biomolecules

In-depth experience in bioconjugate purification techniques including various liquid chromatography methods (e.g. RP, IEX, SEC, HIC, affinity, FPLC) and membrane filtrations (e.g. TFF)

Prior experience in biochemistry techniques and analytical methods such as SEC-MALs, LCMS, SPR/BLI, ELISA, SDS-PAGE, enzyme activity assays, etc.

Willingness to learn new bioconjugation chemistries or delivery modalities and work across diverse therapeutic areas to develop protein therapeutics.

Strong analytical mindset and chemistry problem-solving with creative thinking

The position requires organization skills, attention to detail, self-motivation, and strong teamwork in a fast-paced setting

Education:

Ph.D. in Chemical Engineering, Chemical Biology, Chemistry, or related fields is required; Scientist 1 will have 0-2 years of industry/post-doc experience relating to drug development

Strong foundation in macromolecular chemistry, bioconjugation, analytical chemistry and/or chemical biology is strongly desired.

A record of accomplishments/publications in relevant scientific discipline and some hands-on experience in oligonucleotide delivery is preferred but not required.

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