Scientist I, Upstream Development for Protein Development and Manufacturing

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Job description

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Summary:

Vaxcyte is seeking a talented and motivated Scientist I to join the Upstream Process Development group within the Protein Development and CMC team. This is an exciting opportunity to join an outstanding team with a mission to enhance process understanding of cell free protein synthesis to support scale-up and commercialization of Vaxcyte lead vaccine candidates.

The successful candidate will have the following skills and qualities:
Hands-on experience with developing and optimizing CFPS processes.
Strong fundamental understanding of critical CFPS components.
A clear communicator with strong organizational and planning skills.
A team player who works seamlessly with others, speaks up, and remains focused on achieving the best results to meet company goals.
Essential Functions:

• Design and execute small-scale CFPS process development and process characterization experiments in Ambr250.
• Utilize advanced techniques and technologies to characterize and improve cell free synthesis processes
• Analyze experimental data and present results at project meetings.
• Take an active role in technical documentation initiatives, including authorship of SOPs, technical reports, and ELN and database management.
• Mentor junior team members.

Requirements:

• PhD in Chemical Engineering or a related discipline with minimum 2 years of relevant experience and may include postdoc. MS in Chemical Engineering with minimum 5 years of relevant experience. BS with minimum 8 years of relevant experience.
• Strong background in cell free protein synthesis and characterization techniques.
• Familiarity with DoE (Design of Experiments) principles and software.
• Familiarity with regulatory requirements of biotherapeutics. Late-stage process characterization experience is a plus.
• Experience with Ambr250 bioreactor system a plus.

Reports to: Senior Scientist, Upstream Development and Manufacturing

Location: San Carlos, CA

Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.

Salary Range: $125,000 - $133,000

Vaxcyte, Inc.
825 Industrial Road, Suite 300
San Carlos, CA 94070

We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.

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