Associate Engineer II, LNP Process Development

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Job description

Who We Are:

ReCode Therapeutics is a clinical-stage genetic medicines company using precision delivery to power the next wave of mRNA and gene correction therapeutics. ReCode's proprietary Selective Organ Targeting (SORT) lipid nanoparticle (LNP) platform enables highly precise and targeted delivery of genetic medicines directly to the organs, tissues and cells implicated in disease, enabling improved efficacy and potency. ReCode's lead programs include RCT1100 for the treatment of primary ciliary dyskinesia caused by pathogenic mutations in the DNAI1 gene, and RCT2100 for the treatment of the 10-13% of cystic fibrosis patients who have Class I mutations in the CFTR gene and do not respond to currently approved CFTR modulators. RCT1100 and RCT2100 are inhaled disease-modifying mRNA-based therapies formulated using the SORT LNP delivery platform. ReCode is expanding its pipeline to develop potential therapies for other rare and common genetic diseases, including musculoskeletal, central nervous system, liver and infectious disease indications.

Summary of Position:

The Associate Engineer will work as part of a team, under the direction of the group leader/manager, to conduct laboratory experiments to support the development of robust scalable LNP-encapsulated nucleic acids formulations and manufacturing processes, including lab-scale process development, process scaleup, and in-process characterization. The ideal candidate will be proactive, enthusiastic, and show a passion for LNP-RNA formulation and process development. The applicant should have strong communication and collaboration skills, along with a background in LNP formulation and process development.

Specific Responsibilities:

• Executes studies to define formulation components, vehicle, and primary container.
• Operates common biopharmaceutical unit operations such as mixing, dialysis, tangential flow filtration, and sterile filtration.
• Support efforts in fill/finish process optimization, process characterization, technology transfer, and regulatory documentation for our LNP formulations candidates.
• Interface with External Manufacturing, Quality and Regulatory organizations to execute on strategies for GLP or GMP batches
• Performs in-process characterization such as pH, particle size, encapsulation efficiency measurement etc.
• Managing daily pre-formulation/material assessments of LNP screening and development
• Supports troubleshooting and technical investigations as needed.
• Responsible for executing or supporting experiments to meet agreed upon deliverables and timelines.
• Optimize existing formulation methods and processes and generate standard operating procedures (SOPs) and test method documents.
• Maintain thorough and detailed electronic lab notebooks and documentation records.
• Support and participate in R&D and project management meetings. Prepare PowerPoint slides and present your findings to multi-disciplinary teams.
• Adhere to all laboratory safety requirements and procedures.
• Assist in maintaining general laboratory functionality and lab equipment.
• Assist in ordering and receiving of lab supplies.
• Exercises judgment within defined procedures and practices to determine appropriate action.

Qualifications:

• B.S. or M.S. chemical engineering, bioengineering, pharmaceutical sciences.
• Foundation in chemistry, materials science, bio-engineering, chemical engineering, or related field.
• Strong written and oral communication skills, comfort with a "start-up environment".
• Familiarity using CAD software such as Solidworks AutoCAD is an advantage.

Salary Range: $83,000-93,000/year

Please note that for remote positions, salary may be adjusted for cost of living

Benefits Offered for Full-Time Employees:

• No premium cost for employees - 100% subsidized by ReCode for full-time employees
• Company 401k contribution
• 15 days of company paid holidays, including a holiday shutdown (usually the last week of the year)
• Mental health support for employees & their families
• FSA available, including a lifestyle spending account subsidized by company
• Employee discounts at hotspots

ReCode Therapeutics () offers a competitive compensation/benefits package with a friendly, collaborative culture that values employee engagement and ongoing career development.

ReCode Therapeutics is an Equal Opportunity Employer.

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